126 Second Avenue (just South of St. Marks Place)
Seats: 347-seat proscenium
The Orpheum Theatre opened in the 1880s and is one of the oldest sites of continuous entertainment in New York City. It began life as the the Orpheum Concert Gardens, became one of the theaters on the Yiddish theater strip, and eventually ended up as an off-Broadway venue.
Next: P.S. 122